Les, Yes - for .MOV videos that have alpha the best codec to use is the animation codec. For videos without alpha the best codec to use is MotionJPEG. The videos would then need to be transferred to a Windows machine with the XPression Video Coder installed and converted to .AVI wrapper with the XPression Video Codec.
The XPression engine will play out .MOV files (and a number of codecs) natively but better performance can be achieved by converting them using the XPression Video Coder.
#XPression