Ah - I thought you meant changing the alpha (aka transparancy) of the object in XPression.
You are asking specifically about the alpha/key channel of the source video?
We can animate the alpha/transparancy of the object the video material is applied to - but we can't animate/manipulate the alpha/key channel of the source video.
That would need to be done in the original source video.
To be really clear:
#XPression